Anti-Aging · Core Formula

The Anti-Aging Solution ^Rx

Name: The Anti-Aging Solution
Brand: DermClick
Price: 69.00 USD

Tretinoin · Niacinamide

Most Prescribed

Treat face wrinkles and fine lines.

$34.50/month

Starting with a 2-month supply

Free shipping
Skip or delay refills
HSA/FSA eligible
Ongoing support

Treatment list

The Anti-Aging Solution ingredient callouts

The Anti-Aging Solution benefits for fine lines and early aging

The Anti-Aging Solution best for early signs of aging

Anti-Aging · Core Formula

The Anti-Aging Solution ^Rx

Tretinoin · Niacinamide

Most Prescribed

Treat face wrinkles and fine lines.

$34.50/month

Starting with a 2-month supply

Prescription-strength tretinoin, dermatology's most-studied anti-aging active. It smooths fine lines, refines texture, evens tone, and keeps breakouts in check, while niacinamide, Centella asiatica, and ceramides keep your barrier calm through treatment.

Treats the following anti-aging concerns:

Free shipping
Skip or delay refills
HSA/FSA eligible
Ongoing support

Formulations

Gentle

Active ingredients:

Tretinoin 0.025%
Niacinamide 2%

Everyday

Active ingredients:

Tretinoin 0.05%
Niacinamide 2%

Maximum

Active ingredients:

Tretinoin 0.1%
Niacinamide 2%

How & Why It Works

Speeds up skin cell turnover to surface fresher skin
Softens the look of fine lines and wrinkles over time
Helps even tone and fade the look of discoloration
Promotes smoother, more refined texture
Helps keep pores clear, so breakouts show up less often
Supports the skin barrier so treatment stays comfortable
Compounded by a licensed pharmacy for each prescription

As with any prescription retinoid, some people notice mild, temporary effects as their skin adjusts to treatment. These are typically short-lived and manageable with simple care steps.

Common adjustment effects can include mild dryness, peeling, itching, or redness. Applying a moisturizer helps soothe irritation, and most people find their skin settles within the first few weeks. A board-certified dermatologist on our clinical team reviews your case and sets a formulation appropriate for your skin.

How to Use

After cleansing, apply one pump to your fingertips and gently massage onto your face at night — or as directed by the dermatologist on your clinical team.

Follow with a gentle, hydrating moisturizer to keep your skin comfortable as it adjusts.

Wear a broad-spectrum sunscreen, minimum SPF 30, every morning. Tretinoin makes your skin more sensitive to sun, so daily protection isn’t optional.

Most people see visible changes in 6–12 weeks with consistent nightly use
Each bottle is approximately a one-month supply

Pairs Well With

The Precision Dark Spot Corrector

A prescription-strength spot treatment that targets isolated dark spots, sun spots, and stubborn discoloration.

The Redness Control Formula

A daytime prescription that visibly reduces facial redness and flushing.

100% Compounded Online PharmacyPrescription-Only TreatmentsNo Long-Term Commitments

What's The Anti-Aging Solution?

Treats the following anti-aging concerns:

Free shipping
Skip or delay refills
HSA/FSA eligible
Ongoing support

Formulations

Gentle

Active ingredients:

Tretinoin 0.025%
Niacinamide 2%

Everyday

Active ingredients:

Tretinoin 0.05%
Niacinamide 2%

Maximum

Active ingredients:

Tretinoin 0.1%
Niacinamide 2%

How & Why It Works

Speeds up skin cell turnover to surface fresher skin
Softens the look of fine lines and wrinkles over time
Helps even tone and fade the look of discoloration
Promotes smoother, more refined texture
Helps keep pores clear, so breakouts show up less often
Supports the skin barrier so treatment stays comfortable
Compounded by a licensed pharmacy for each prescription

As with any prescription retinoid, some people notice mild, temporary effects as their skin adjusts to treatment. These are typically short-lived and manageable with simple care steps.

How to Use

After cleansing, apply one pump to your fingertips and gently massage onto your face at night — or as directed by the dermatologist on your clinical team.

Follow with a gentle, hydrating moisturizer to keep your skin comfortable as it adjusts.

Wear a broad-spectrum sunscreen, minimum SPF 30, every morning. Tretinoin makes your skin more sensitive to sun, so daily protection isn’t optional.

Most people see visible changes in 6–12 weeks with consistent nightly use
Each bottle is approximately a one-month supply

Pairs Well With

The Precision Dark Spot Corrector

A prescription-strength spot treatment that targets isolated dark spots, sun spots, and stubborn discoloration.

The Redness Control Formula

A daytime prescription that visibly reduces facial redness and flushing.

What our customers are saying.

Video review

★★★★★

“After about six to eight weeks, my skin looked brighter and smoother.”

Before
Dull skin, more fine lines, and uneven texture.
6–8 weeks
Brighter, smoother-looking skin.
Continued use
Some fine lines started to look softer.

“It definitely didn't happen overnight, but I've been really happy with the difference.”

Cristina A. · Verified Buyer

Individual results vary.

Emily's fine lines before and after using The Anti-Aging Solution

BeforeAfter

No makeup, no touchups

★★★★★

“The fine lines on my forehead are so much softer”

“I started noticing fine lines across my forehead and around my eyes in my early 30s, especially when I wasn't wearing makeup. I had used retinol before, but I wanted to try something prescription-strength before those lines became more noticeable. I've been using the Anti-Aging Solution for about five months now and the change has been gradual but really noticeable. My forehead looks smoother, the fine lines around my eyes aren't as obvious, and my skin texture looks much more even. I still look completely like myself—my skin just looks healthier and smoother than it did a few months ago.”

Emily, 34 · Verified Buyer

Lauren's skin texture before and after using The Anti-Aging Solution

BeforeAfter

No makeup, no touchups

★★★★★

“My skin texture is completely different”

“Texture was the thing that bothered me most. My skin had started looking rough and uneven, especially across my cheeks and forehead, and I felt like foundation actually made it more obvious. I started DermClick about four months ago. The first few weeks I had some dryness while my skin adjusted, so I took it slowly and used plenty of moisturizer. Now my skin feels much smoother and looks more refined. I also notice that my tone is more even. The difference isn't that I suddenly look ten years younger—it's that my skin itself looks much better.”

Lauren, 39 · Verified Buyer

Megan's fine lines before and after using The Anti-Aging Solution

BeforeAfter

No makeup, no touchups

★★★★★

“I wanted to start before my lines got deeper”

“I'm 31, so I wasn't looking for a dramatic anti-aging treatment. I had just started seeing fine lines around my eyes and a little bit across my forehead, and my skin wasn't looking as bright as it used to. I'd spent enough money on retinol serums that didn't seem to do much, so I decided to try prescription tretinoin through DermClick. I've been using it consistently for a little over four months. My skin looks brighter and smoother, and those early lines are much less noticeable. This is exactly what I wanted—something I can keep using long-term instead of waiting until aging becomes a much bigger concern.”

Megan, 31 · Verified Buyer

Simone's skin before and after using The Anti-Aging Solution

BeforeAfter

No makeup, no touchups

★★★★★

“I didn't realize how dull my skin had become”

“For me it wasn't one big wrinkle that bothered me. My whole complexion had started looking tired—uneven tone, some sun-related discoloration, fine lines and just a generally dull appearance. I've been using the Anti-Aging Solution for almost six months now. The biggest difference is the overall quality of my skin. It looks clearer, smoother and more even, and the fine lines around my eyes have softened. I still have normal lines when I smile, which I expect, but when I look at photos from before I started, my skin definitely looks healthier now.”

Simone, 42 · Verified Buyer

Erica's skin before and after using The Anti-Aging Solution

BeforeAfter

No makeup, no touchups

★★★★★

“Finally something that helps my lines and my occasional breakouts”

“I thought by my late 30s I would be done worrying about breakouts, but apparently my skin had other plans. I was getting occasional spots around my chin while also starting to notice fine lines and uneven texture. I've been using the Anti-Aging Solution for about five months and my skin is noticeably smoother and clearer. I don't get clogged areas as often, and the fine lines across my forehead look softer. I love having one simple prescription in my nighttime routine instead of constantly switching between products for breakouts and products for aging.”

Erica, 37 · Verified Buyer

Jessica's skin before and after using The Anti-Aging Solution

BeforeAfter

No makeup, no touchups

★★★★★

“I can see the difference when I'm not wearing makeup”

“By my mid-40s I had started noticing fine lines around my eyes and mouth, uneven texture and some discoloration from years of not being as careful with sunscreen as I should have been. I wasn't looking to erase every line on my face—I just wanted my skin to look better. After about six months with DermClick, that's exactly what has happened. My skin looks smoother and more even, some of the finer lines have softened, and overall my face looks fresher without makeup. The changes happened gradually, but comparing where I started to where I am now makes the difference really obvious.”

Jessica, 45 · Verified Buyer

The clinical team

The medicine behind your prescription is built by the doctors you already follow.

The Anti-Aging Solution^Rx wasn't formulated by an algorithm or pulled from a generic template. Its protocol was designed by Dr. Lindsey Zubritsky, Dr. Mamina Turegano, and Dr. Jenny Liu — three board-certified dermatologists with combined decades of clinical experience treating women who want to start prescription anti-aging before the concerns get harder to address. Your prescription is then written by a board-certified dermatologist on our clinical team, working from the protocol they built. Dermatologist-built medicine, delivered to your door.

Dr. Lindsey Zubritsky MDDr. Mamina Turegano, MDDr. Jenny Liu, MD

What's in the bottle

Real actives. Named, not hidden.

The Anti-Aging Solution ^Rx pairs one prescription retinoid with three supporting ingredients designed to keep your barrier intact and your skin comfortable while the medication does its work. Four ingredients. One purpose. No marketing language wrapped around the names.

Active Ingredients

Tretinoin

THE CORRECTOR

A prescription-strength retinoid — roughly 100× more potent than the strongest over-the-counter retinol. Accelerates cell turnover, smooths fine lines, evens tone, and builds collagen over time. The single most-studied anti-aging active in dermatology.

Niacinamide

THE BUFFER

A form of vitamin B3 that reduces redness, evens tone, and supports your skin barrier. Makes the retinoid more tolerable from week one — and quietly improves the look of your skin on its own.

Supporting Ingredients

Centella Asiatica

THE CALMER

A clinically studied botanical that soothes irritation during the adjustment period. Used in dermatology for decades for its barrier-supporting properties. The reason your first weeks on tretinoin won't feel like a punishment.

Ceramides

THE BARRIER REPAIR

Lipids that reinforce the skin barrier and lock in moisture. Retinoid tolerance comes down to barrier health — ceramides keep yours strong enough to stay on treatment long enough to see results.

Exact concentrations are determined by your dermatology provider based on your assessment, your tolerance, and your skin's history. Compounded medications are not FDA-approved.

What to expect

A reset for clearer, smoother, more even skin.

Woman applying anti-aging cream under her eye

The Anti-Aging Solution^Rx works while you sleep. Tretinoin accelerates cell turnover and builds collagen over time — the single mechanism behind both smoother texture and softer fine lines. Niacinamide evens tone and reduces redness, Centella asiatica soothes the adjustment period, and ceramides reinforce your barrier so the retinoid does its job without compromising your skin's comfort.

Smooths fine lines and uneven texture
Boosts tone, clarity, and overall skin quality
Builds collagen over time with consistent use
Improves how your skin looks in the mirror — and over the years

Built for the woman who's done waiting on retinol.

The Anti-Aging Solution ^Rx is a Core-tier prescription. That means it's strong enough to actually move the needle on fine lines, texture, and tone — and gentle enough to be your first prescription anti-aging treatment, not your last resort.

Ideal for you if you're

Starting to notice fine lines, early texture changes, dullness, or uneven tone
Tired of OTC retinols that promise prescription-strength results without the prescription
Wanting to stay ahead of aging before the concerns get harder to reverse
Ready for your first prescription anti-aging treatment — or stepping up from over-the-counter retinols that have stopped delivering
Able to tolerate a prescription retinoid, as confirmed during your assessment

Consider a different fit if you're:

Dealing with deeper wrinkles, loss of firmness, or visible photoaging — The Advanced Anti-Aging Solution^Rx is built for higher-intensity cases
Pregnant, nursing, or trying to conceive — tretinoin isn't appropriate; your assessment will route you to a safer option
Primarily concerned about active acne — The Acne Solution^Rx is built for that
Mostly dealing with persistent redness or rosacea flushing — The Redness Control Formula^Rx is built for that
Already on isotretinoin (Accutane), or finished a course within the past 6 months — we'll need to space your treatment appropriately

Realistic timeline

What you may see in 6–12 weeks.

Prescription retinoid treatment isn't a one-week fix. Real anti-aging results take time — but they're real, they hold, and they compound.
Here's what most people experience:

Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.

Smiling woman touching her neck after a skincare routine

Weeks 1–2

Adjustment

Your skin gets used to the prescription. You may notice mild dryness, peeling, or temporary sensitivity. This is the medication doing its job — and the barrier-support ingredients keep it tolerable.

Weeks 3–6

Calming

The adjustment settles. Your skin texture starts to feel smoother. Tone begins to look more uniform. This is the point most people feel the shift.

Weeks 7–12

Visible smoothing

Fine lines look softer. Skin looks brighter and more even. The dullness lifts. Your skin starts to look like a smoother, fresher version of itself.

Beyond 12 weeks

Maintenance and collagen building

Tretinoin's long-term work — collagen building, sustained smoothness, sustained tone — compounds over months and years. Your dermatology care team checks in and adjusts your formula as your skin evolves.

Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.

How DermClick works

Three steps. No appointments. Reviewed by a board-certified dermatologist within one business day.

Tell us about your skin.

Take our skin assessment. Share your concerns, your skin's history, what you've tried before, and a few photos. The more we know, the better the formula.

Close-up of uneven tone and pigmentation

One business day review

Your case is reviewed in 24 business hours, and your prescription is written by a licensed dermatology provider.

DermClick dermatologist reviewing a formula on a laptop

Tretinoin

Niacinamide

Your prescription arrives

Your formula is compounded by a licensed pharmacy and shipped to your door — usually within a week. Your dermatologist stays with you, adjusting your formula as your skin responds.

DermClick prescription bottle and box inside a delivery package

See the full process →

Frequently Asked Questions

Why not just use a retinol from Sephora?

Because OTC retinols are roughly 1/100th the potency of prescription tretinoin — that's regulation, not marketing. If your over-the-counter retinol was going to smooth your fine lines and even your tone, it would have done it by now. Tretinoin is the same active your dermatologist would prescribe in-office, calibrated to your tolerance and supported with niacinamide, Centella asiatica, and ceramides so you can actually stay on it. The strength difference is the entire point.

Should I start with The Anti-Aging Solutionᴿˣ or the Advanced version?

The Anti-Aging Solutionᴿˣ is our first-line prescription anti-aging formula — built around tretinoin, ideal for people starting to notice fine lines, early texture changes, dullness, or uneven tone. The Advanced Anti-Aging Solutionᴿˣ is the maximum-strength tier — built around tazarotene, a next-generation retinoid, for deeper wrinkles, loss of firmness, and more visible photoaging. If you're not sure, take the assessment. A board-certified dermatologist on your care team will tell you which one matches where your skin actually is — not where you think it should be.

Will I 'purge' on tretinoin if I don't have acne?

If you don't have active breakouts, you typically won't experience the breakout-style purge that acne patients see on tretinoin. What you may experience instead is a short adjustment period: mild dryness, peeling, or sensitivity as your skin gets used to the increased cell turnover. This usually lasts 2 to 6 weeks. The ceramides and Centella asiatica in the formula are included specifically to keep this phase manageable. If it gets uncomfortable, message us and we'll adjust your ramp-up or your formula.

Can I use this with my current skincare routine, or do I have to start over?

Most of your routine can stay. Gentle cleansers, hydrating serums, broad-spectrum SPF (especially important on tretinoin), and barrier-supporting moisturizers all pair well with The Anti-Aging Solutionᴿˣ. What you should pause: other topical retinoids (additional tretinoin, adapalene, tazarotene, retinol), strong exfoliants like glycolic acid or salicylic acid at high concentrations, vitamin C serums at night (use them in the morning instead), and physical scrubs. A board-certified dermatologist on your care team will review your current products during your assessment and tell you exactly what to keep, what to drop, and what to add.

Is The Anti-Aging Solutionᴿˣ safe with pregnancy, nursing, or other medications?

The assessment specifically asks. The Anti-Aging Solutionᴿˣ contains tretinoin, which is not safe during pregnancy or while nursing. If any of these apply to you, a board-certified dermatologist on your care team will route you to a safer alternative. If we can't safely prescribe for you, we'll tell you before charging you. We don't write prescriptions that shouldn't be written.

When will I see results?

Most people start noticing a real shift between weeks 6 and 12 with consistent nightly use. Weeks 1–2 are the adjustment period. Weeks 3–6, your texture starts to smooth and your tone begins to even out. Weeks 6–12, fine lines look softer and your skin looks brighter overall. Beyond 12 weeks, the collagen-building work compounds over months and years. Tretinoin treatment is steady, not dramatic — but the results hold, and they're the closest thing in topical skincare to actually slowing the visible aging process.

Where can I find full safety information?

Full prescribing details, including side effects, drug interactions, and who shouldn't use this treatment, are available on our Important Safety Information page. We recommend reading it before starting treatment.

The Anti-Aging Solution ^Rx is our first-line prescription anti-aging formula. If your concerns are more visible — deeper lines, loss of firmness, visible photoaging — there's a maximum-strength tier built for that.

Core