Adapalene
THE CORRECTOR
A prescription-strength retinoid. Unclogs pores, supports clearer texture, and helps calm the breakouts forming under the surface before you see them.The Acne SolutionRx
Adapalene · Clindamycin Phosphate · Niacinamide
Clearer, calmer breakouts for
$34.50/month
Starting with a 2-month supply
- Free shipping
- Skip or delay refills
- HSA/FSA eligible
- Ongoing support
The Acne SolutionRx
Adapalene · Clindamycin Phosphate · Niacinamide
Clearer, calmer breakouts for $34.50/month
Starting with a 2-month supply
A prescription acne treatment built with three prescription-strength actives: adapalene to unclog pores, clindamycin to target the bacteria behind active breakouts, and niacinamideto keep your skin comfortable while they work, with centella asiatica and ceramides supporting your barrier throughout. It's a real prescription, designed for your skin and delivered to your door.
Treats the following acne concerns:
- Free shipping
- Skip or delay refills
- HSA/FSA eligible
- Ongoing support
Formulations
Active ingredients:
- Adapalene: 0.3%
- Clindamycin Phosphate 1%
- Niacinamide: 2%
How & Why It Works
- Speeds up skin cell turnover to clear clogged pores
- Calms the bacteria behind active, inflamed breakouts
- Helps reduce oiliness and keep pores looking clear
- Fades the look of post-acne marks over time
- Supports smoother, more even-looking texture
- Supports the skin barrier so treatment stays comfortable
- Compounded by a licensed pharmacy for each prescription
As with any prescription retinoid, some people notice mild, temporary effects as their skin adjusts to treatment, sometimes called “the purge.” These are typically short-lived and manageable with simple care steps.
Common adjustment effects can include mild dryness, peeling, or a temporary increase in breakouts, usually in the first 2 to 4 weeks. Applying a moisturizer helps ease irritation, and most people find their skin settles as the medication starts working. A board-certified dermatologist on our clinical team reviews your case and sets a formulation appropriate for your skin.
How to Use
After cleansing, apply a pea-sized amount to your fingertips and gently massage onto your face at night, or as directed by the board-certified dermatologist on your clinical team.
Follow with a gentle, hydrating moisturizer to keep your skin comfortable as it adjusts.
Wear a broad-spectrum sunscreen, minimum SPF 30, every morning. Prescription retinoids like adapalene can make your skin more sensitive to sun, so daily protection isn’t optional.
- Most people see visible changes in 6–12 weeks with consistent nightly use
- Each bottle is approximately a one-month supply
Pairs Well With
The Red Mark Solution
A prescription formula that helps fade the look of post-acne red marks and even out tone.
100% Compounded Online PharmacyPrescription-Only TreatmentsNo Long-Term Commitments
What's The Acne Solution?
A prescription acne treatment built with three prescription-strength actives: adapalene to unclog pores, clindamycin to target the bacteria behind active breakouts, and niacinamideto keep your skin comfortable while they work, with centella asiatica and ceramides supporting your barrier throughout. It's a real prescription, designed for your skin and delivered to your door.
Treats the following acne concerns:
- Free shipping
- Skip or delay refills
- HSA/FSA eligible
- Ongoing support
Formulations
Active ingredients:
- Adapalene: 0.3%
- Clindamycin Phosphate 1%
- Niacinamide: 2%
How & Why It Works
- Speeds up skin cell turnover to clear clogged pores
- Calms the bacteria behind active, inflamed breakouts
- Helps reduce oiliness and keep pores looking clear
- Fades the look of post-acne marks over time
- Supports smoother, more even-looking texture
- Supports the skin barrier so treatment stays comfortable
- Compounded by a licensed pharmacy for each prescription
As with any prescription retinoid, some people notice mild, temporary effects as their skin adjusts to treatment, sometimes called “the purge.” These are typically short-lived and manageable with simple care steps.
Common adjustment effects can include mild dryness, peeling, or a temporary increase in breakouts, usually in the first 2 to 4 weeks. Applying a moisturizer helps ease irritation, and most people find their skin settles as the medication starts working. A board-certified dermatologist on our clinical team reviews your case and sets a formulation appropriate for your skin.
How to Use
After cleansing, apply a pea-sized amount to your fingertips and gently massage onto your face at night, or as directed by the board-certified dermatologist on your clinical team.
Follow with a gentle, hydrating moisturizer to keep your skin comfortable as it adjusts.
Wear a broad-spectrum sunscreen, minimum SPF 30, every morning. Prescription retinoids like adapalene can make your skin more sensitive to sun, so daily protection isn’t optional.
- Most people see visible changes in 6–12 weeks with consistent nightly use
- Each bottle is approximately a one-month supply
Pairs Well With
The Red Mark Solution
A prescription formula that helps fade the look of post-acne red marks and even out tone.
The clinical team
The medicine behind your prescription is built by the doctors you already follow.
The Acne SolutionRx wasn't formulated by an algorithm or pulled from a generic template. Its protocol was designed by Dr. Lindsey Zubritsky, Dr. Mamina Turegano, and Dr. Jenny Liu — three board-certified dermatologists with decades of combined experience treating real patients. Your prescription is then written by a board-certified dermatologist on our clinical team, working from the protocol they built. Dermatologist-built medicine, delivered to your door.
Dr. Lindsey Zubritsky MDDr. Mamina Turegano, MDDr. Jenny Liu, MD
What's in the bottle
Real actives. Named, not hidden.
The Acne SolutionRx pairs three prescription actives with two supporting ingredients designed to keep your barrier comfortable while the medication does its work.
Active Ingredients
Clindamycin Phosphate
THE TARGETED ANTIBIOTIC
A topical antibiotic that calms the bacteria driving active, inflamed breakouts — working on what's already on your skin while adapalene works on what's coming.
Niacinamide
THE BUFFER
A form of vitamin B3 that helps reduce redness, supports your skin barrier, and makes prescription actives more tolerable. Irritation is the top reason people quit retinoids — this is the reason you won't.Supporting Ingredients
Centella Asiatica
THE CALMER
A clinically studied botanical that soothes irritation and supports recovery. The quiet ingredient that keeps the strong ones comfortable.
Ceramides
THE BARRIER REPAIR
Lipids that reinforce the skin barrier and lock in moisture. Barrier health is what lets you stay on treatment — ceramides protect the foundation.Exact concentrations are determined by your dermatology provider based on your assessment, your tolerance, and your skin's history. Compounded medications are not FDA-approved.
What to expect
A nightly reset for clearer-looking skin.
The Acne SolutionRx works while you sleep. Prescription-strength adapalene unclogs pores, clindamycin phosphate calms the bacteria behind active breakouts, and niacinamide keeps your barrier comfortable through the process.
- Helps clear active breakouts
- Unclogs pores and reduces oiliness
- Fades post-acne marks over time
- Supports clearer, more even skin texture
- Gentle enough for first-time prescription users
Your best skin starts here.
The Acne SolutionRx is a Core-tier prescription. That means it's strong enough to actually move the needle on breakouts you've been trying to clear on your own — and gentle enough to be your first prescription, not your last resort.
Ideal for you if you're
Dealing with mild to moderate acne — breakouts that come back no matter what you swap into your routine.
Tired of stacking OTC products that promise prescription-strength results without the prescription.
Noticing clogged pores, oiliness, or post-acne marks alongside the breakouts themselves.
Ready for your first prescription — or stepping up from over-the-counter retinoids like adapalene 0.1% (Differin) that have stopped working.
Able to tolerate a prescription retinoid, as confirmed during your assessment.
Consider a different fit if you're:
Dealing with severe acne-prone skin or deep breakouts that are leaving lasting marks — The Advanced Acne Solutionᴿˣ is built for higher-intensity cases.
Pregnant, nursing, or trying to conceive —many of our actives aren't appropriate; your assessment will route you to a safer option.
Primarily concerned about fine lines or signs of aging — The Anti-Aging Solution is built for that.
Mostly dealing with persistent redness or rosacea flushing — The Redness Control Formula is built for that.
Already on isotretinoin (Accutane),or finished a course within the past 6 months — we'll need to space your treatment appropriately.
Real results, from real routines.
I'd been using Differin for over a year and hit a wall. Three months into The Acne Solution and my breakouts have basically stopped. Wish I'd switched sooner.
Maya T.
Weeks two and three were rough — they warned me about the purge and they were right. But by week eight my skin was clearer than it's been since high school. Stick with it.
Jordan K.
One bottle at night instead of the five-step routine I'd cobbled together. My skin is calmer, less oily, and the marks from old breakouts are finally fading.
Priya S.
Realistic timeline
What you may see in 6–12 weeks.
Prescription acne treatment isn't a one-week fix. Real results take time — but they're real, and they hold.
Here's what most people experience:
Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.
Weeks 1–2
Adjustment
Your skin gets used to the prescription. You may notice mild dryness, peeling, or a temporary increase in breakouts as clogged pores work their way to the surface. This is the medication doing its job.Weeks 3–6
Calming
Active breakouts may start to slow. Visible irritation looks calmer. Your skin's texture begins to even out. This is the point most people feel the shift.Weeks 7–12
Visible clearing
Fewer new breakouts. Pores look smaller. Post-acne marks begin to fade. Your skin starts to look like a calmer version of itself.Beyond 12 weeks
Maintenance and adjustment
Your DermClick care team checks in. If your skin has plateaued or needs more support, your formula is adjusted. This is where most acne treatments fall apart — and where we're built differently.Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.
How DermClick works
Three steps. No appointments. Reviewed by a board-certified dermatologist within one business day.
Tell us about your skin.
Take our skin assessment. Share your concerns, your skin's history, what you've tried before, and a few photos. The more we know, the better the formula.
One business day review
Your case is reviewed within one business day, and your prescription is written by a board-certified dermatologist on our clinical team.
Adapalene
Clindamycin Phosphate
Niacinamide
HydroquinoneYour prescription arrives
Your formula is compounded by a licensed pharmacy and shipped to your door — usually within a week. Your DermClick care team stays with you, adjusting your formula as your skin responds.
Frequently Asked Questions
Should I start with The Acne Solutionᴿˣ or step up to The Advanced Acne Solutionᴿˣ?
The Acne Solutionᴿˣ is our Core-tier formula for mild to moderate acne-prone skin and for people who haven't been on a prescription retinoid before. The Advanced Acne Solutionᴿˣ is the Advanced tier — higher-intensity actives, formulated for stubborn acne-prone skin with deep or recurring breakouts that haven't responded to over-the-counter or first-line prescription care. If you're not sure, take the assessment. A board-certified dermatologist on your care team will tell you which one matches where your skin actually is — not where you think it should be.
Will I get "the purge" with this?
Possibly, in the first 2 to 4 weeks. Adapalene accelerates cell turnover, which can push clogged material to the surface before it clears. This isn't the prescription making things worse — it's the prescription doing its job. Most people get through the adjustment period and come out the other side with clearer skin. The niacinamide and Centella asiatica in the formula are included specifically to keep this phase manageable.
Can I use this with my current skincare routine, or do I have to start over?
Most of your routine can stay. Gentle cleansers, fragrance-free moisturizers, and broad-spectrum SPF all pair well with The Acne Solutionᴿˣ. What you should pause: other topical retinoids (additional adapalene, tretinoin, tazarotene, retinol), high-concentration acids (salicylic, glycolic, lactic), and benzoyl peroxide — which can deactivate adapalene when layered directly. A board-certified dermatologist on your care team will review your current products during your assessment and tell you exactly what to keep, drop, and add.
Is The Acne Solutionᴿˣ safe with pregnancy, nursing, or other medications?
The assessment specifically asks. Many of our actives aren't appropriate during pregnancy or nursing — if any of these apply to you, a board-certified dermatologist on your care team will route you to a safer alternative. If we can't safely prescribe for you, we'll tell you before charging you. We don't write prescriptions that shouldn't be written.
When will I see results?
Most people start noticing a real shift between weeks 4 and 8 with consistent nightly use. Weeks 1–2 are the adjustment period. Weeks 3–6, breakouts may start to slow and visible irritation can look calmer. Weeks 6–12, fewer new breakouts, smaller-looking pores, and post-acne marks begin to fade. Acne-prone skin care is steady, not dramatic — but the results can hold.
What type of skin is The Acne Solutionᴿˣ designed for?
It's designed for mild to moderate acne-prone skin — particularly skin that breaks out consistently regardless of routine changes, shows clogged pores and oiliness alongside active breakouts, or has tried OTC retinoids like adapalene 0.1% (Differin) without getting the results a prescription concentration delivers. It's gentle enough for sensitive skin and designed for daily use without the harshness that comes with stronger acne formulas.
Where can I find full safety information?
Full prescribing details, including side effects, drug interactions, and who shouldn't use this treatment, are available on our Important Safety Information page. We recommend reading it before starting treatment.
The Acne SolutionRx is our Core-tier acne treatment, built for mild to moderate breakouts. If your skin needs more — or less — there's a tier built for that. Your assessment routes you to the one that fits.
The Redness & Acne Formula
Azelaic Acid · Glycolic Acid · Niacinamide
$36.00/mo
Billed every 2 months. Cancel anytime. Skip or delay refills. Total per cycle: $72.00.
A multitasking prescription formula that helps calm redness, clear breakouts, and fade the marks they leave behind.
Targets:Redness · Breakouts · Post-acne marks · Uneven tone
The Advanced Acne Solution
Adapalene · Benzoyl Peroxide · Clindamycin · Niacinamide
$44.50/mo
Billed every 2 months. Cancel anytime. Skip or delay refills. Total per cycle: $89.00.
A higher-strength prescription formula for stubborn, inflamed breakouts that need more support.
Treats:Stubborn acne · Inflammation · Clogged pores
The Red Mark Solution
Tranexamic Acid · Kojic Acid · Niacinamide
$35.00/mo
Billed every 2 months. Cancel anytime. Skip or delay refills. Total per cycle: $70.00.
A prescription formula that helps fade the look of post-acne red marks and even out tone.
Treats:Post-acne red marks · P.I.E. · Uneven tone