Anti-aging · Maximum strength
Tazarotene · Niacinamide
Maximum-strength renewal for skin that's past what tretinoin can do.
$44.50/month
Starting with a 2-month supply
Anti-aging · Maximum strength
The Advanced Anti-Aging Solution Rx
Tazarotene · Niacinamide
Maximum-strength renewal for skin that's past what tretinoin can do.
$44.50/month
Starting with a 2-month supply
Tazarotene is dermatology's most potent topical retinoid, selected when first-line tretinoin isn't enough. It works on deeper wrinkles, texture, and firmness, while niacinamide, Centella asiatica, and ceramides keep your barrier calm through maximum-strength treatment.
Treats the following anti-aging concerns:
Maximum strength
Active ingredients:
Exact concentrations are determined by a board-certified dermatologist on our clinical team based on your assessment, your tolerance, and your skin's history. Compounded medications are not FDA-approved.
As with any prescription retinoid, some people notice mild, temporary effects as their skin adjusts to treatment. With a maximum-strength retinoid like tazarotene, this adjustment period can feel sharper than it does with first-line tretinoin, and it typically settles within the first few weeks.
Common adjustment effects can include dryness, peeling, itching, or redness. Applying a moisturizer helps soothe irritation, and most people find their skin settles as treatment continues. A board-certified dermatologist on our clinical team reviews your case and sets a formulation appropriate for your skin.
At night, apply a thin, pea-sized layer to clean, dry skin, 20 to 30 minutes after washing. That amount covers the whole face. More won't work faster, it will only irritate.
Ramp up gradually: every third night for two weeks, every other night in weeks 3 and 4, then nightly as your skin tolerates it. The dermatologist on your clinical team sets and adjusts your plan. Advanced needs a slower start than Core.
Follow with a barrier-supporting moisturizer.
Every morning, wear a broad-spectrum SPF 30 or higher. Tazarotene makes skin significantly more sun-sensitive than first-line retinoids, and that lasts for weeks after stopping.
Do not use if you are pregnant, may become pregnant, trying to conceive, or breastfeeding. Tazarotene is FDA Pregnancy Category X and can cause birth defects. Effective contraception is required during treatment. If you become pregnant, stop use and contact your DermClick care team.
The Dark Spot Solution
A hydroquinone-free prescription that fades melasma, sun spots, and post-acne marks, the tone and pigment concerns tazarotene works alongside. Contains tretinoin, so your clinical team sets how the two are sequenced.
The Redness Control Formula
A daytime prescription that visibly calms the redness and flushing that maximum-strength tazarotene can stir up early on. No retinoid, no overlap, built to sit alongside your nightly formula.
Tazarotene is dermatology's most potent topical retinoid, selected when first-line tretinoin isn't enough. It works on deeper wrinkles, texture, and firmness, while niacinamide, Centella asiatica, and ceramides keep your barrier calm through maximum-strength treatment.
Treats the following anti-aging concerns:
Maximum strength
Active ingredients:
Exact concentrations are determined by a board-certified dermatologist on our clinical team based on your assessment, your tolerance, and your skin's history. Compounded medications are not FDA-approved.
As with any prescription retinoid, some people notice mild, temporary effects as their skin adjusts to treatment. With a maximum-strength retinoid like tazarotene, this adjustment period can feel sharper than it does with first-line tretinoin, and it typically settles within the first few weeks.
Common adjustment effects can include dryness, peeling, itching, or redness. Applying a moisturizer helps soothe irritation, and most people find their skin settles as treatment continues. A board-certified dermatologist on our clinical team reviews your case and sets a formulation appropriate for your skin.
At night, apply a thin, pea-sized layer to clean, dry skin, 20 to 30 minutes after washing. That amount covers the whole face. More won't work faster, it will only irritate.
Ramp up gradually: every third night for two weeks, every other night in weeks 3 and 4, then nightly as your skin tolerates it. The dermatologist on your clinical team sets and adjusts your plan. Advanced needs a slower start than Core.
Follow with a barrier-supporting moisturizer.
Every morning, wear a broad-spectrum SPF 30 or higher. Tazarotene makes skin significantly more sun-sensitive than first-line retinoids, and that lasts for weeks after stopping.
Do not use if you are pregnant, may become pregnant, trying to conceive, or breastfeeding. Tazarotene is FDA Pregnancy Category X and can cause birth defects. Effective contraception is required during treatment. If you become pregnant, stop use and contact your DermClick care team.
The Dark Spot Solution
A hydroquinone-free prescription that fades melasma, sun spots, and post-acne marks, the tone and pigment concerns tazarotene works alongside. Contains tretinoin, so your clinical team sets how the two are sequenced.
The Redness Control Formula
A daytime prescription that visibly calms the redness and flushing that maximum-strength tazarotene can stir up early on. No retinoid, no overlap, built to sit alongside your nightly formula.
No makeup, no touchups
“I'd been using tretinoin for years and felt like my skin had stopped changing. Around month three on the Advanced formula, I started noticing that the deeper lines across my forehead and around my eyes looked softer. My skin still looks like my skin — just smoother and more refreshed.”
Karen W., 56 · Verified Buyer
No makeup, no touchups
“I was nervous about stepping up to something stronger, and the first few weeks were definitely an adjustment. I had some dryness, but once that settled, the difference in my skin texture became really noticeable. Four months in, my cheeks look smoother and my skin feels firmer than it did before.”
Vanessa L., 52 · Verified Buyer
No makeup, no touchups
“Years of being out in the sun had really started showing on my face, especially around my eyes and cheeks. I'm five months in now and the rough texture has improved a lot, and some of the deeper lines don't look as pronounced. I wasn't expecting perfect skin — I just wanted healthier-looking skin, and that's what I'm seeing.”
Diane C., 61 · Verified Buyer
No makeup, no touchups
“The lines around my mouth were the thing that bothered me most because they were starting to look deeper even when my face was relaxed. After about four months, I noticed they looked softer and the skin around my mouth and cheeks looked smoother overall. It was gradual, but comparing my photos made the difference obvious.”
Michelle R., 58 · Verified Buyer
No makeup, no touchups
“I've tried plenty of anti-aging products over the years, so I wasn't expecting an overnight transformation. This took patience. Somewhere between months three and four I realized the deeper lines on my forehead looked less harsh, and my whole face had a smoother texture. At six months, I'm still seeing improvement.”
Patricia M., 64 · Verified Buyer
No makeup, no touchups
“My biggest concern was the crepey texture and lines around my eyes. I could see them even when I wasn't smiling. The first month was mostly about getting my skin used to the formula, but by month three I could see a difference. I'm at five months now and that whole area looks smoother, without looking unnatural.”
Angela T., 54 · Verified Buyer
The clinical team
The Advanced Anti-Aging Solution Rx wasn't formulated by an algorithm or pulled from a generic template. Its protocol was designed by Dr. Lindsey Zubritsky, Dr. Mamina Turegano, and Dr. Jenny Liu — three board-certified dermatologists with combined decades of clinical experience treating patients at every stage of aging.
Your prescription is then written by a board-certified dermatologist on our clinical team, working from the protocol they built. Dermatologist-built medicine, delivered to your door.
What's in the bottle
The Advanced Anti-Aging Solution Rx pairs one maximum-strength prescription retinoid with three supporting ingredients designed to keep your barrier comfortable through higher-intensity treatment. Four ingredients. One purpose.
Active Ingredients
THE CORRECTOR
A next-generation prescription retinoid selected for more intensive texture, tone, and firmness support than first-line tretinoin. This is the active that separates Advanced from Core.
THE BUFFER
A form of vitamin B3 that evens tone, reduces redness, and improves tolerance of maximum-strength actives. One of three reasons your skin can stay on tazarotene long enough to see what it can do.Supporting Ingredients
THE CALMER
A clinically studied botanical that soothes irritation and supports recovery. Used in dermatology for decades. The quiet ingredient that keeps the loud ones comfortable.
THE BARRIER REPAIR
Lipids that reinforce the skin barrier and lock in moisture. With maximum-strength actives, barrier health is the limiting factor in how long you can stay on treatment. Ceramides protect the foundation.Exact concentrations are determined by a board-certified dermatologist on your care team based on your assessment, your tolerance, and your skin's history. Compounded medications are not FDA-approved.
What to expect
The Advanced Anti-Aging Solution Rx works while you sleep. Tazarotene is selected when stronger retinoid support is appropriate for deeper lines, visible photoaging, and firmness concerns. Niacinamide evens tone, Centella asiatica soothes the higher-intensity adjustment, and ceramides reinforce your barrier so you can stay on the formula long enough to see results.
Deeper wrinkles, visible photoaging, loss of firmness that first-line retinoids haven't touched.
The Advanced Anti-Aging Solution Rx is our maximum-strength prescription anti-aging formula. Tazarotene and niacinamide work together as co-actives, supporting texture, tone, and firmness, while Centella asiatica and ceramides keep your barrier intact through the more intense adjustment period.
Dealing with deeper wrinkles, loss of firmness, or visible photoaging
You've been on prescription tretinoin and plateaued, or stopped seeing results
Watching texture changes, sun damage, or sagging develop alongside the lines
Looking for stronger results than first-line prescription anti-aging can deliver
Familiar with prescription retinoids and able to tolerate a maximum-strength formulation, as confirmed during your assessment
New to prescription retinoids. The Anti-Aging SolutionRx (Core) is the better starting point and steps up cleanly if needed
Pregnant, nursing, or trying to conceive. Tazarotene is FDA Pregnancy Category X and is contraindicated; your assessment will route you to a safer option
Currently fighting active breakouts alongside aging. The Advanced Acne FormulaRx is built for that
Primarily dealing with melasma or persistent pigmentation. The Brightening SolutionRx is built for that
Already on isotretinoin (Accutane), or finished a course within the past 6 months. We'll need to space your treatment appropriately
Realistic timeline
Maximum-strength prescription anti-aging isn't a one-week fix — and the concerns you're addressing took years to develop. Real results take time. They also hold. Here's what most people experience.
Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.
Weeks 1–2
Weeks 3–6
Weeks 7–12
Beyond 12 weeks
Results vary. Timelines depend on your starting skin, your formula strength, and how consistently you apply your treatment.
Three steps. No appointments. Reviewed by a board-certified dermatologist within one business day.
Take our skin assessment. Share your concerns, your skin's history, what you've tried before, and a few photos. The more we know, the better the formula.
Your case is reviewed within one business day, and your prescription is written by a board-certified dermatologist on our clinical team.
Tazarotene
NiacinamideYour formula is compounded by a licensed pharmacy and shipped to your door — usually within a week. Your dermatologist stays with you, adjusting your formula as your skin responds.
The Anti-Aging Solutionᴿˣ is our first-line prescription formula, built around tretinoin, ideal for fine lines, early texture changes, and dullness. The Advanced Anti-Aging Solutionᴿˣ is the maximum-strength tier, built around tazarotene, a next-generation retinoid stronger than tretinoin, formulated for deeper wrinkles, loss of firmness, and visible photoaging that hasn't responded to first-line treatment. If you're not sure, take the assessment. A board-certified dermatologist on your care team will tell you which one matches where your skin actually is, not where you think it should be.
Tazarotene is a next-generation prescription retinoid that's typically more potent than tretinoin and is used when deeper texture, tone, and firmness concerns need stronger support. That power comes with a sharper adjustment period: more dryness, more peeling, more sensitivity, especially in the first 4 to 8 weeks. That's why the Advanced formula includes ceramides and Centella asiatica for barrier support — they make tazarotene livable. If your skin has plateaued on tretinoin, this is typically the next step.
If you don't have active breakouts, you typically won't experience a breakout-style purge. What you may experience instead is a more pronounced adjustment period than with first-line tretinoin: moderate dryness, peeling, or sensitivity for 2 to 8 weeks as your skin acclimates to the higher-strength active. The ceramides and Centella asiatica in the formula are included specifically to keep this phase manageable. If it gets uncomfortable, message us and we'll adjust your ramp-up or your formula.
Most of your routine can stay. Gentle cleansers, hydrating serums, broad-spectrum SPF (non-negotiable on tazarotene), and barrier-supporting moisturizers all pair well with The Advanced Anti-Aging Solutionᴿˣ. What you should pause: other topical retinoids (tretinoin, adapalene, additional tazarotene, retinol), strong exfoliants like glycolic acid or salicylic acid at high concentrations, vitamin C serums at night (use them in the morning instead), and physical scrubs. A board-certified dermatologist on your care team will review your current products during your assessment and tell you exactly what to keep, what to drop, and what to add.
The assessment specifically asks. The Advanced Anti-Aging Solutionᴿˣ contains tazarotene, which is FDA Pregnancy Category X — it is contraindicated during pregnancy due to risk of birth defects, and effective contraception is required during treatment for anyone who could become pregnant. It is also not recommended while nursing. If any of these apply to you, a board-certified dermatologist on your care team will route you to a safer alternative. If we can't safely prescribe for you, we'll tell you before charging you. We don't write prescriptions that shouldn't be written.
Most people start noticing a real shift between weeks 8 and 12 with consistent nightly use. Here's roughly what to expect: weeks 1–2 are the adjustment period. Weeks 3–6, your texture starts to smooth and your tone begins to even out. Weeks 6–12, deeper lines look softer and your skin looks firmer. Beyond 12 weeks, the collagen-building and sun-damage-correcting work compounds over months and years. Maximum-strength treatment is steady, not dramatic — but the results hold, and they're the strongest thing in topical anti-aging short of in-office procedures.
The Advanced Anti-Aging Solutionᴿˣ is a prescription tazarotene treatment, so it carries important safety information you should read before starting, covering who should not use it, pregnancy warnings, possible side effects, and how to use it. You can read the full Important Safety Information here. If you have questions about your own case, message your DermClick care team.
The Advanced Anti-Aging Solution Rx is our maximum-strength anti-aging formula, built for deeper lines, visible photoaging, and skin that's plateaued on first-line treatment. If you're earlier in treating the signs of aging, The Anti-Aging SolutionRx is the starting point, with a clear step-up path when you're ready. And if sun damage and uneven tone are part of your picture alongside the lines, The Brightening SolutionRx is built to pair with it. Your assessment routes you to what fits — and tells you what works together.
Tretinoin · Niacinamide
$34.50/mo
Billed every 2 months. Cancel anytime. Skip or delay refills. Total per cycle: $69.00.
The dermatologist go-to — one prescription retinoid that helps clear breakouts and smooth fine lines, paired with niacinamide to calm irritation.
Targets:Fine lines · Texture · Breakouts · Clogged pores · Uneven tone
Tranexamic Acid · Kojic Acid · Tretinoin · Niacinamide
$35.50/mo
Billed every 2 months. Cancel anytime. Skip or delay refills. Total per cycle: $71.00.
A hydroquinone-free prescription formula that fades stubborn dark spots and uneven tone from multiple angles.
Targets:Stubborn dark spots · Uneven tone · Post-acne marks · Dullness
Hydroquinone · Kojic Acid · Tretinoin · Niacinamide
$36.00/mo
Billed every 2 months. Cancel anytime. Skip or delay refills. Total per cycle: $72.00.
A four-active prescription formula that helps fade dark spots and even out tone with prescription-strength brightening.
Targets:Dark spots · Melasma · Uneven tone · Post-acne marks