Important Safety Information

The Red Mark Solution^Rx

Please read this information carefully before using your prescription. Keep it for reference, and message your DermClick care team if you have any questions.

What it is

The Red Mark Solution^Rx is a compounded prescription topical medication, formulated by a licensed compounding pharmacy for individual patients under the direction of a licensed dermatology provider, working from protocols built by DermClick's founding board-certified dermatologists. It is designed for treatment of post-acne marks (PIE), not for active acne.

Active ingredients

Tranexamic acid - an antifibrinolytic active used in dermatology to calm post-inflammatory signalsKojic acid - a melanin-inhibiting active for brightening uneven toneNiacinamide - a barrier-supporting vitamin B3 derivative that visibly reduces redness

Inactive ingredients

Licorice root extract - a botanical brightening agent for diminishing post-acne marks

What it treats

The Red Mark Solution^Rx is prescribed for the treatment of:

Post-inflammatory erythema (PIE), the pink and red marks left after acne heals
Post-acne discoloration and uneven tone
Mild post-inflammatory hyperpigmentation associated with healed acne lesions
Lingering dullness and uneven complexion in patients whose acne has resolved
Sensitivity-driven discoloration in recovering skin

Your dermatology provider has determined this formulation is appropriate for your specific skin based on the assessment you completed.

Who should not use it

Do not use The Red Mark Solution^Rx if any of the following apply to you. If your situation changes after your assessment, contact your DermClick care team before continuing use.

You have a known allergy or sensitivity to tranexamic acid, kojic acid, niacinamide, licorice root, or any other listed ingredient
You are pregnant, planning to become pregnant, or nursing, so consult your dermatology provider before starting
You have a history of severe blood clotting disorders or are on anticoagulation therapy, so discuss with your dermatology provider before starting (oral tranexamic acid has clotting precautions; topical risk is much lower but disclosure applies)
You have used oral isotretinoin, commonly known as Accutane, within the past 6 months
You have an active skin infection, severe eczema, or open wounds in the application area
You have severe active acne, so treat active breakouts first before starting recovery treatment
You are under 12 years of age

Warnings and precautions

Active acne

The Red Mark Solution^Rx does not treat active acne. If you are still experiencing active breakouts, your dermatology provider will route you to an acne formula (The Acne Solution^Rx or The Advanced Acne Solution^Rx) first. Some patients eventually use both - an acne formula for prevention and The Red Mark Solution^Rx for the marks left behind - but only when active acne is under control.

Pregnancy and nursing

Topical kojic acid and tranexamic acid have limited safety data during pregnancy. Do not start this treatment during pregnancy or while nursing without explicit guidance from your dermatology provider. If your pregnancy status changes during treatment, contact your DermClick care team immediately.

Sun sensitivity

UV exposure prolongs and worsens post-inflammatory marks, both red (PIE) and brown (PIH). Apply broad-spectrum SPF 30 or higher every morning, every day, including cloudy days. Without consistent SPF, the formula is working against active UV damage at the same time as fading marks, which slows results significantly.

Skin barrier sensitivity

This formula is designed for already-healing, sensitive skin. Mild tingling or temporary sensitivity during the first 2 weeks is common but should settle. If sensitivity persists or worsens, contact your DermClick care team.

Acne scars vs. acne marks

The Red Mark Solution^Rx treats acne marks (flat discoloration in healed skin). It does not treat acne scars (structural changes such as ice-pick, boxcar, or rolling scars). If your concern is raised or pitted scarring, in-office procedures (microneedling, laser, subcision, fillers) are the appropriate treatment. Your dermatology provider can help you understand which you are dealing with.

Realistic expectations

Post-acne mark recovery is gradual. Newer marks fade faster than older ones, and marks present for over a year may take longer to respond. Meaningful change typically develops over 6 to 12 weeks of consistent daily use plus daily SPF.

Eye, lip, and nostril contact

Avoid contact with eyes, lips, the corners of the nose, and any mucous membranes. If contact occurs, rinse thoroughly with cool water.

Waxing and laser treatments

Pause use of The Red Mark Solution^Rx for at least one week before and after waxing, laser treatments, or chemical peels on the application area. Consult your DermClick care team.

Licorice root sensitivity

Some patients are sensitive to topical botanical brightening agents. If you experience itching, redness, or hives at the application site, stop use and contact your DermClick care team.

Drug interactions

Tell your dermatology provider about any prescription or over-the-counter medications you use, especially:

Other topical brightening or pigmentation treatments, including hydroquinone, additional kojic acid, or additional tranexamic acid
Topical retinoids, including tretinoin, adapalene, tazarotene, or retinol, which should be discussed with your dermatology provider before layering
Other alpha-hydroxy or beta-hydroxy acids at high concentrations
Benzoyl peroxide products, which can deactivate some brightening actives if used in the same step
Topical or oral corticosteroids in the application area
Anticoagulants, such as warfarin, heparin, or similar medications, which should be disclosed to your dermatology provider

Possible side effects

Common side effects

These may happen especially in the first 1 to 2 weeks of treatment.

Mild tingling or stinging on application
Temporary mild dryness
Mild redness or warmth at the application site
Slight sensitivity to skincare products that did not bother you before
Mild irritation in particularly sensitive areas

Less common side effects

Persistent dryness or sensitivity beyond the adjustment period
Contact dermatitis or allergic reaction at the application site
Temporary worsening of marks, known as a paradoxical reaction, which usually resolves with continued consistent use
Localized burning or itching
Mild localized acne breakouts

These are typical of post-acne recovery prescription treatment and usually settle within the first 1 to 2 weeks as your skin adjusts. This formula is designed for already-healing skin and is gentler than active acne treatments. Your DermClick care team can adjust your application frequency if symptoms become uncomfortable.

Rare but serious

Contact your DermClick care team or seek emergency care if you experience:

Severe rash, hives, or swelling of the face, lips, tongue, or throat
Difficulty breathing
Signs of severe allergic reaction
Severe blistering or skin sloughing at the application site

How to use it

Application

Apply a thin layer to clean, dry skin in the evening, after washing your face and patting it dry. Apply across areas with post-acne marks, typically cheeks, jaw, forehead, and chin. Can be used across the full face if your dermatology provider directs.

Frequency

Once nightly. Your DermClick care team may start you at every other night for the first week if your skin is particularly sensitive, then move to nightly.

Amount

A pea-sized amount is enough for the full face. More is not better and can cause unnecessary irritation without improving results.

Layering with other treatments

If you are using an acne treatment (The Acne Solution or The Advanced Acne Solution), your dermatology provider will design the layering, typically the acne formula is applied first, with The Red Mark Solution either layered on top or alternated by night. Your assessment will set the protocol.

Storage

Store at room temperature, away from direct sunlight and heat. Keep the cap closed when not in use. Do not freeze.

Shelf life

Use within the period indicated on your prescription label. Do not use after the expiration date.

Morning

Gentle, fragrance-free cleanser, then moisturizer, then broad-spectrum SPF 30+ (essential, every morning, every day)

Evening

Gentle cleanser, then any acne treatment (if prescribed), then The Red Mark Solution^Rx, then a barrier-supporting fragrance-free moisturizer.

If you have a reaction

For mild irritation

Reduce application to every other night, apply a fragrance-free, barrier-supporting moisturizer 10 to 15 minutes after the medication, and message your DermClick care team. We can adjust your formula or your application protocol.

For moderate to severe reactions

Stop using the medication. Message your DermClick care team. Send photos if you can so your dermatology provider can review and respond.

For medical emergencies

For severe rash, swelling of the face or throat, difficulty breathing, or signs of severe allergic reaction, call 911 or go to your nearest emergency room immediately.

Contact your DermClick care team

Phone: 1-833-496-4045
Email: support@dermclick.com
Account dashboard: message your care team directly at app.dermclick.com

Message your care team

About compounded medications

Compounded medications are prepared by a licensed compounding pharmacy for individual patients, based on a prescription written by a licensed dermatology provider. They are not individually evaluated or approved by the FDA.

The active ingredients in The Red Mark Solution^Rx- tranexamic acid, kojic acid, niacinamide, and licorice root - are well-established ingredients used in clinical dermatology for post-inflammatory marks, individually and in combination. Compounding allows your dermatology provider to combine them into a single nightly formulation tailored to your skin, rather than asking you to layer multiple separate brightening serums on top of already-healing skin. The supporting ingredients aren't optional extras - they are what makes the formula gentle enough for sensitive, recovering skin.

Your prescription is compounded by a 503A licensed compounding pharmacy and shipped directly to you.

The Red Mark SolutionRx