The Advanced Acne Solution is a prescription gel that adds a fourth active to the lineup, making it a stronger, more comprehensive option for tougher or more persistent breakouts. It works on acne from four angles:
- Adapalene — a retinoid that keeps pores clear and helps calm the inflammation behind breakouts
- Benzoyl peroxide — kills acne-causing bacteria and helps prevent the antibiotic resistance that can come with long-term clindamycin use
- Clindamycin phosphate — targets acne-causing bacteria on the skin
- Niacinamide — supports the skin barrier and helps with redness and oil
It's rounded out with two supporting ingredients: Centella Asiatica extract, which soothes, and ceramides, which help your barrier hold onto moisture so the actives are easier to tolerate.
The gel comes in four strengths — 0.3%, 1%, 2%, and 2.5%. You don't pick the strength yourself, and there's no upcharge for a higher one. After you complete your medical intake, a board-certified dermatologist reviews your case and decides which strength fits your skin, your history, and how much your skin can handle from the start.